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KMID : 0614619940260020369
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Korean Journal of Gastroenterology
1994 Volume.26 No. 2 p.369 ~ p.372
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A Case of Propylthiouracil induced Hepatitis
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박현주
정인성/강성원/조한래/한설혜/한경아/김주형/임양희/오경식
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Abstract
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Propylthiouracil(PTU) is widely used to treat patients with hyperthyroidism. In rare case, this drug has been found to have toxic effects on the liver. We experienced a case of PTU induced hepatitis in a 45-year old woman treated for Grawes'
disease
with PTU. The biochemical pattern of injury was predominantly hepatocellular with moderately elevated transminase values and histologic findings revealed marked micro and macrovesicular fatty changes and focal necrosis of hepatocytes without any
zonal
difference. Discontinuation of drug leads to complete recovery in this case. Although overt hepatitis due to PTU is probably a rare complication, there is a potential danger of permanent liver damage. Thus is might be advisable to monitor
transaminase
levels on regular base in patients receiving PTU. (Korean J Gastroenterol 1994 ; 26 : 369-372)
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